The research group Synthetic and Catalytic Methodologies works at the Research Center for Advanced Scientific Research (CICA) within the group of Molecular Chemistry and Materials. The research is focused on the development methodologies for the synthesis of organic compounds of interest, bioactive compounds or new organic materials. The synthetic tools are mainly related to Organometallic Chemistry and with the use of transition metals in organic synthesis. Since 1997, this research group has developed different projects associated with the synthesis of bioactive natural products, sustainable chemical processes and new reactions of formation of carbon-carbon and carbon-heteroatom bonds. Of particular relevance are the investigations on organometallic indium in reactions catalyzed by transition metals.

OUR GROUP

News

14/01/2026

A new article from the group is now published in Organic Chemistry Frontiers. Congratulations for the beautiful chemistry behind this work.

https://pubs.rsc.org/en/content/articlelanding/2026/qo/d5qo01388g

 

 

Recent publications

Tandem indium(III)-catalyzed cyclization and intermolecular hydrofunctionalization of 1,6-enynes

Raquel Pérez-Guevara, Diego Folgueira-Iravedra, Lorena Alonso-Marañón, M. Montserrat Martínez and José Pérez Sestelo *

Org. Chem. Front., 2026, 13, 1560–1565 | https://doi.org/10.1039/D5QO01388G

Pyrimidine-based compounds as promising anticancer agents targeting tumor cell senescence

Paula Carpintero-Fernández,  M. Montserrat Martínez,  Alexander Carneiro-Figueira, Rebeca Martínez, Alejandro García-Yuste, Marta Barturen-Gómez, Cristina Pérez-Caaveiro, Amanda Guitián-Caamaño, Luis A. Sarandeses, José Pérez Sestelo, and María D. Mayán

Molecular Therapy Oncology, 2026; 34 |  https://doi.org/10.1016/j.omton.2026.201129

Synthesis of BODIPYs using organoindium reagents and survey of their cytotoxicity and cell uptake on nervous system cells

Ana Da Lama, Natalia Fernández-Bertólez, Lorena Colás, Miguel No-Gómez, Pedro Ramos-Cabrer, Vanessa Valdiglesias, Luis A Sarandeses, M. Montserrat Martínez

Bioorganic Chemistry 2025, 155, 108107 (10.1016/j.bioorg.2024.108107)