The research group Synthetic and Catalytic Methodologies works at the Research Center for Advanced Scientific Research (CICA) within the group of Molecular Chemistry and Materials. The research is focused on the development methodologies for the synthesis of organic compounds of interest, bioactive compounds or new organic materials. The synthetic tools are mainly related to Organometallic Chemistry and with the use of transition metals in organic synthesis. Since 1997, this research group has developed different projects associated with the synthesis of bioactive natural products, sustainable chemical processes and new reactions of formation of carbon-carbon and carbon-heteroatom bonds. Of particular relevance are the investigations on organometallic indium in reactions catalyzed by transition metals.




Despite the lab space limitations due to COVID-19 three new enthusiastic undergraduate students, Aldara Asenjo Rodríguez (left), Rubén González Peteiro (center) and Juan Luis Méndez Alvarez (right) have joint the research group to prepare their final degree work.

Recent publications

Advances in Cross-Coupling Reactions

José Pérez Sestelo and Luis A. Sarandeses

Molecules 2020, 25, 4500; doi:10.3390/molecules25194500

Transition-Metal-Free Oxidative Cross-Coupling of Triorganoindium Reagents with Tetrahydroisoquinolines

Gil-Negrete, J. M.; Pérez Sestelo, J.; Sarandeses, L. A.


J. Org. Chem. 2019, 84, 9778-9785. DOI:

Synthesis of D-A-A and D-A-D Pyrimidine π-Systems Using Triorganoindium Reagents: Optical, Vibrational and Electrochemical Studies

Pérez-Caaveiro, C.; Moreno Oliva, M.; López Navarrete, J. T.; Pérez Sestelo, J.; Martínez, M. M.; Sarandeses, L. A.


J. Org. Chem. 2019, 84, 8870-8885. DOI: